The influence of Pediococcus acidilactici and Saccharomyces cerevisiae as probiotics on the porcine immunity and bacterial Translocation

The influence of P. acidilactici and S. cerevisiae, on immunity and bacterial translocation in piglets was evaluated.Litters were allocated to the following treatments:1) Control without antibiotic or 2) with tiamulin as antibiotic; 3) P. acidilactici; 4) S. Cerevisiae; and 5) the 2 probiotics. A treatment by day interaction indicated that CD8+ cell population in the ileum was increased in P. acidilactici compared to the 2 probiotics and control before weaning whereas there was no difference after weaning. A treatment by day interaction showed that CD4-CD8high cell population was increased before weaning in P. acidilactici compared to 2 probiotics and to control. After challenge, bacterial translocation was higher in control than in other groups. The influence of the 2 probiotics on establishment of mononuclear cells in the intestine and on bacterial translocation after challenge suggests that these probiotics could protect the host against bacterial invasion and be beneficial for the health of the host.